Research
Dr. François Dragon - Université du Québec à Montréal
QBCF Strategic Grants Program
Research Factsheet
DR. FRANÇOIS DRAGON
UNIVERSITÉ DU QUÉBEC À MONTRÉAL
PROJECT TITLE Regulation of ribosome biogenesis in cancer cells
PRINCIPAL INVESTIGATOR Dr. François Dragon
INSTITUTE Université du Québec à Montréal
TOTAL RESEARCH BUDGET $120,000
RESEARCH SUMMARY*:
Ribosomes are the “factories ” that synthesize proteins in all living organisms. Making ribosomes is essential for cells to grow in size and proliferate, an activity that has gone uncontrolled in cancer cells. Cancers can result from deregulation or mutation of genes involved in ribosome production. The purpose of this research project is to determine whether a gene and a protein (DDX10 and AATF) participate in ribosome biogenesis, and how mutations in DDX10 affect its interaction with AATF, and if they affect cellular growth. Overall, our research will shed light on molecular events that regulate ribosome biogenesis and cell growth.
* This document is a non-scientific summary.
